Dosage forms of drugs orally and gastroretentive for continuous release of highly soluble drugs.

摘要

The invention relates to medicaments freely or very readily soluble in water, and are produced in unit dosage form incorporating into hydrophilic polymers consisting of a high molecular weight which swell when water imbibed polymeric matrices. The dosage form may be a single tablet or two or three tablets retained in a capsule single gelatin. This oral formulation is intended to be retained in the stomach and regulated manner diffuses the medicament containing the gastric cavity. With this method of administration, the drug is released from the matrix in gastric fluid by solution-diffusion. Once it reaches a sufficient size, the swollen polymeric matrix remains in the gastric cavity for several hours if the drug has been administered to the patient while it feeds, and remains long enough to allow a substantially complete drug release before it produces a significant erosion of the matrix. The swellable matrix reduces gastric fluid access to the drug thus limits the release rate of the drug. This procedure together with the delay spread by the selection of specific polymer molecular weight polymer and other variables result given cone speed controlled sustained drug release in the gastric environment.