INDOLINONA COMBINATORY LIBRARIES AND RELATED PRODUCTS AND METHODS FOR THE TREATMENT OF DISEASES.

摘要

THE PRESENT INVENTION REFERS TO ORGANIC MOLECULES, ABLE TO MODULATE, REGULATE AND / OR INHIBIT THE TRANSDUCTION OF THE PROTEIN KINASE SIGNAL. THESE COMPOUNDS ARE USEFUL FOR THE TREATMENT OF DISEASES RELATED TO THE TRANSDUCTION OF THE SIGN OF THE PROTEIN QUINASA NOT REGULATED, INCLUDING CELLULAR PROLIFERATION DISEASES AS CANCER, ARTERIOSCLEROSIS, ARTHRITIS AND RESTENOSES, METHODSET. THE INVENTION DESCRIBES INDOLINONE COMPOUNDS THAT POTENTLY INHIBIT THE PROTEIN KINASES, AS WELL AS RELATED PRODUCTS AND PROCEDURES. SPECIFIC INHIBITORS CAN BE OBTAINED FOR THE FLK KINASE PROTEIN, BY ADDING CHEMICAL SUBSTITUTES TO 3 - [(INDOL 3 - IL) METHYLENE] - 2 - INDOLINONE, ESPECIALLY IN THE 1 '' POSITION OF THE INDOL RING. INDOLINONE COMPOUNDS THAT SPECIFICALLY INHIBIT THE FLK KINASE PROTEIN AND THE GROWTH FACTOR DERIVED FROM PLATES, CAN HAVE A TETRAHYDROINDOL OR CYCLOPENTANE FRACTION - B - PIRROL. INDOLINONE COMPOUNDS THAT ARE MODIFIED BY SUBSTITUTES, ESPECIALLY IN POSITION 5 OF THE OXINDOL RING, CAN ACTIVATE THE PROTEIN KINASES EFFECTIVELY. THE INVENTION ALSO DESCRIBES NEW HYDROSOLUBLE INDOLINONE COMPOUNDS THAT ARE INHIBITORS OF THYROSINE KINASE, AS WELL AS RELATED PRODUCTS AND PROCEDURES.