USEFUL TETRAHYDROBENZAZEPIN DERIVATIVES AS MODULATORS OF D3 DOPAMINE RECEPTORS (ANTI-PSYCHOTIC AGENTS).

摘要

A compound of ** formula ** in which: R1 represents a substituent selected from: a hydrogen or halogen atom; a hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethanesul fonyloxy, pentafluoroethyl, C1-4 alkyl, C1-4 alkoxy, arylC 1-4 alkoxy, (C1-4) alkyl thio, C1-4 alkoxy group - C 1-4 alkyl, C 3-6 cycloalkyl-C 1-4 alkoxy, C 1-4 alkanoyl, C 1-4 alkoxycarbonyl, C 1-4 alkyl sulfonyl, C 1-4 alkyl sulfonyloxy, alkyl (C1-4) sulfonyl-C1-4 alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonyl-C1-4 alkyl, alkylsulfonamido, (C1-4) alkyl amido, (C1-4) sulfonamido-C1-4 alkyl, alkyl (C1-4) amido-C1-4 alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamido-C1-4 alkyl, arylcarboxamido-C1-4 alkyl, aroyl, C1-4 alkyl-aryl, or C1- aryl-alkanoyl 4; a group R3OCO (CH2) P, R3CON (R4) (CH2) P, R3R4NCO (CH2) P or R3R4NSO2 (CH2) p, in each of whose formulas R3 and R4, independently, represents a hydrogen atom or an alkyl group C1-4 or R3R4 is part of a C3-6 azacycloalkane or C3-6 (2-oxo) azacycloalkane ring and p represents zero or an integer from 1 to 4; or an Ar3-Z group, in which Ar3 represents a phenyl ring or a 5- or 6-membered aromatic heterocyclic ring, both of which are optionally substituted with one or more substituents selected from hydrogen, halogen, amino, cyano, alkyl C1-4, alkyl (C1-4) amino, dialkyl (C1-4) amino, alkyl (C1-4) amido, C1-4 alkanoyl or R5R6NCO in whose formula each of R5 and R6 independently represents a hydrogen atom or a C1-4 alkyl group and Z represents a bond, O, S or CH2; R2 represents a hydrogen atom or a C1-4 alkyl group.