ORAL PHARMACEUTICAL PREPARATION UNDERSTANDING AN ANTIQULCEROUS ACTIVITY COMPOUND AND PROCEDURE FOR OBTAINING IT.

摘要

It comprises an inert core; a soluble or rapidly disintegrating active layer in water obtained from a single aqueous or hydroalcoholic suspension solution comprising: an active principle of antiulcer activity of formula (I, II or III), and at least one excipient; and a gastro-resistant outer coating layer obtained from a solution comprising: an enteric coating polymer; and at least one excipient. The procedure is carried out by 1) a coating of the inert nuclei by the nebulization of the only suspension-aqueous or hydroalcoholic solution; 2) a drying of the active layer formed during the fogging of the previous stage; and 3) a coating of the charged cores by nebulizing a solution comprising an enteric coating polymer with at least one excipient to obtain a gastro-resistant outer coating layer.