MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS

摘要

Substituted heterocycles of general structural formula (I) or apharmaceutically acceptable salt thereof, wherein: R1 is selected from thegroup consisting of: hydrogen; C1-6 alkyl, unsubstituted or substituted; C2-6alkenyl, unsubstituted or substituted; C2-6 alkynyl; phenyl, unsubstitued orsubstituted; X is selected from the group consisting of: -O-, -S-, -SO-, -SO2-; Y is selected from the group consisting of: a single bond, -O-, -S-, -CO-, -CH2, -CHR5- and -CR15R16; Z = C1-6 alkyl, are tachykinin receptor antagonistsuseful in the treatment of inflammatory diseases, pain or migraine, asthma andemesis, and calcium channel blockers useful in the treatment of cardiovascularconditions such as angina, hypertension or ischemia.