A thin layer for sample analysis by matrix-assisted laser desorption massspectrometry, comprising a matrix material in a supporteddispersion wherein the support is a solid or is formed from a solid. Theinvention is also directed to a method of making a thin layer forsample analysis by matrix-assisted laser desorption mass spectrometry, thelayer comprising a matrix-solid composition disposed upon asubstrate, comprising the step of depositing a solution containing matrix,solid and solvent upon a spinning substrate at a deposition ratesufficient to allow evaporation of the solvent, thereby interspersing thematrix and support on the substrate in a thin layer. Enhanced massresolution is described.
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