NEW METHOD FOR DOPAMINE MEASUREMENT AND DIAGNOSES AND FOLLOWING UP OF PSYCHOSIS

摘要

This invention relates to a new rapid and economical spectrophotometric methodwas applied for microdetermination of dopamine in pharmaceutical preparationsand in urine samples of psychotic patients e.g. schizophrenic patients. Thisprocedure depends on the formation of coloured complex between dopamine,copper sulfate and 4~aminoantipyrine under selected optimum conditions. Theproposed procedure can be applied (1) to control the quantity of dopamine inpharmaceutical preparations (2) with psychiatric physician, which allows themto (a) detection the psychosis early which help in treatment and prevention ofthe disease e.g. screen study (b) diagnose of the disease (c) follow up theschizophrenic patients, (d) to control the dose of treatment and (f)prevention of relapse in patients on anti-psychotic drugs or with history ofthe disease.