PHARMACEUTICAL COMPOSITIONS OF AMORPHOUS ATORVASTATIN AND PROCESS FOR PREPARING SAME

摘要

Solid pharmaceutical compositions containing atorvastatin are disclosed. Thecompositions include a solid dispersion of amorphous atorvastatin and one ormore optional pharmaceutically acceptable excipients. The solid dispersion isprepared by mixing crystalline atorvastatin with a melt-processible polymerand an optional stabilizer and an optional plasticizer at a temperaturesufficiently high to soften or melt the polymer and to melt or dissolve thecrystalline atorvastatin in the polymer, thereby forming a dispersion ofamorphous atorvastatin.