TARGETED PLASMINOGEN ACTIVATOR FUSION PROTEINS AS THROMBOLYTIC AGENTS

摘要

This invention relates to novel fusion proteins, comprising a targetingprotein and a plasminogen activator, preferably an antibody that binds to P-selectin, operably linked to the plasminogen activator DSPAalphal, or analogs,frag~ments, derivatives, or variants thereof, which are useful as thrombolyticagents. Pharmaceutical compositions containing these fusion proteins, methodsof using these fusion proteins as thrombolytic agents, and processes forsynthe~sizing these fusion proteins are also described herein.