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TARGETED PLASMINOGEN ACTIVATOR FUSION PROTEINS AS THROMBOLYTIC AGENTS
TARGETED PLASMINOGEN ACTIVATOR FUSION PROTEINS AS THROMBOLYTIC AGENTS
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机译:靶向溶酶原激活剂融合蛋白作为溶栓剂
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摘要
This invention relates to novel fusion proteins, comprising a targeting protein and a plasminogen activator, preferably an antibody that binds to P-selectin, operably linked to the plasminogen activator DSPAalpha1, or analogs, fragments, derivatives, or variants thereof, which are useful as thrombolytic agents. Pharmaceutical compositions containing these fusion proteins, methods of using these fusion proteins as thrombolytic agents, and processes for synthesizing these fusion proteins are also described herein.
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