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Sphingosine kinase interacts with TRAF2 and modulates tumor necrosis factor-induced cellular activity
Sphingosine kinase interacts with TRAF2 and modulates tumor necrosis factor-induced cellular activity
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机译:鞘氨醇激酶与TRAF2相互作用并调节肿瘤坏死因子诱导的细胞活性
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摘要
The present invention relates generally to a method of modulating cytokine-mediated cellular activity and to agents useful for same. More particularly, the present invention contemplates a method of modulating tumor necrosis factor-mediated cellular activity by modulating an intracellular sphingosine kinase-dependent signalling mechanism. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate cytokine-mediated cellular activity The present invention is further directed to methods for identifying and/or designing agents capable of modulating the subject sphingosine kinase-dependent signalling mechanism.
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