Screening method for a reprogramming agent, reprogramming agent screened by the method, method for using the reprogramming agent, method for differentiating an undifferentiated fusion cell, and production method of cells, tissues and organs.

摘要

A method for screening reprogramming factors comprises treatment of somatic cells with a component originating in ES (embryonic stem) cells, detecting it's activity and selecting a component that has reprogramming activity. Independent claims are also included for: (1) reprogramming factors contained in ES cells; (2) a method for reprogramming somatic cells by treating with the reprogramming factor; (3) a method for producing cells, tissues or organs by treating somatic cells with the reprogramming factor for their reprogramming, and differentiating the reprogrammed cells; (4) a method for constructing cells, tissues or organs by producing undifferentiated fused cells from ES cells and somatic cells before differentiating such fused cells; and (5) cells, tissues or organs thus obtained.