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Glycosylphosphatidylinositol glycan signalling via integrins functioning as glycan specific receptors
Glycosylphosphatidylinositol glycan signalling via integrins functioning as glycan specific receptors
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机译:通过整联蛋白的糖基磷脂酰肌醇糖基聚糖信号转导聚糖特异性受体
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摘要
The present invention relates generally to a method of modulating integrin-mediated cellular activity and to agents useful for same. More particularly, the present invention contemplates a method of modulating ab integrin-mediated cellular activity by modulating GPI-related signalling. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate integrin-mediated cellular activity. The present invention is further directed to methods for identifying and/or designing agents capable of modulating the subject integrin dependent signalling mechanism.
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