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ANGIOTENSIN-CONVERTING ENZYME-2 AS A RECEPTOR FOR THE SARS CORONAVIRUS
ANGIOTENSIN-CONVERTING ENZYME-2 AS A RECEPTOR FOR THE SARS CORONAVIRUS
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机译:血管紧张素转化酶2作为SARS冠状病毒的受体
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摘要
The present invention is based upon the identification of human angiotensinconverting enzyme-2 (ACE-2) as a functional receptor for the SARS coronavirus. Transfection of cells with ACE-2 confers upon them the ability to support viral replication. In addition, assays performed using ACE-2 together with the S protein of the SARS virus or a fragment derived from the S protein can be used to identify inhibitors that block the interaction between virus and host cell.
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