VARIOUS HUMAN CHROMOSOMAL REGIONS IMPLICATED IN PREMATURE CANITIES

摘要

Use of at least one polynucleotide fragment comprising at least 18 consecutive nucleotides the sequence of which corresponds to all or part of the region of the human chromosome 1 included between the markers D1S2797 and D1S2868, or between the marker D1S2842 and the telomer q, or to that of the region of the human chromosome 2 included between the markers D2S149 and D2S392, or of the region of the human chromosome 2 included between the markers D2S347 and D2S142, or of the region of the human chromosome 3 included between the markers D3S3567 and D3S1277, or between the markers D3S1285 and D3S3653, or of the region of the human chromosome 4 included between the markers D4S1501 and D4S408, or of the region of the human chromosome 6 included between the markers D6S308 and D6S1581, or of the region of the human chromosome 7 included between the markers D7S657 and D7S530, or between the markers D7S1824 and D7S615, or of the region of the human chromosome 9 included between the markers D9S1677 and D9S1682, or of the region of the human chromosome 10 included between the markers D10S591 and D10S547, or of the region of the human chromosome 12 included between the markers D12S310 and D12S85, or between the markers D12S99 and D12S364, or of the region of the human chromosome 15 included between the markers D15S1040 and D15S641, or between the markers D15S978 and D15S153, or of the region of the human chromosome 16 included between the markers D16S503 and D16S516, or between the markers D16S3030 and D16S50, or of the region of the human chromosome 18 included between the markers D18S464 and D18S1102, or of the region of the human chromosome 19 included between the markers D19S216 and D19S221, or of the region of the human chromosome 20 included between the markers D20S107 and D20S100, use of agents capable of modifying the function associated with one of these regions, use of expression products of one of these regions and use of agents capable of modifying the function of these expression products for cosmetic, therapeutic or diagnostic purposes.