REDUCTION OF HIV-1 REPLICATION BY A MUTANT APOLIPOPROTEIN B MRNA EDITING ENZYME-CATALYTIC POLYPEPTIDE-LIKE 3 G (APOBEC3G)

摘要

Mutant APOBEC3G sequences are provided herein that reduce HIV-1 infection in the presence of HIV-Vif. In particular examples, mutant APOBEC3G molecules include (or encode for) a D128A, D128E, D128K, or D128V substitution. Methods of using the disclosed molecules for reducing HIV-1 infection are also provided, for example to treat a subject having an HIV-1 infection.