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PROCESS FOR HIGH THROUGHPUT LIQUID OR GAS CHROMATOGRAPHY/MASS SPECTROMETRY-BASED BIOMOLECULAR SCREENING FOR DRUG DISCOVERY
PROCESS FOR HIGH THROUGHPUT LIQUID OR GAS CHROMATOGRAPHY/MASS SPECTROMETRY-BASED BIOMOLECULAR SCREENING FOR DRUG DISCOVERY
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机译:高通量液体或基于气相色谱/质谱的生物分子筛查药物发现的过程
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摘要
Methods of achieving realistic hit rates and reducing or eliminating false positive rates in medicinal compound high throughput screening are provided. The methods of the invention include chromatographic resolution, for example by liquid or gas chromatography of biological substrates and/or substrate products, followed by sensitive with mass spectrometry to measure biological activity screening to generate meaningful drug leads. The methods of the invention save significant method development and thus are directly applicable to the high throughput screening time scale while providing high accuracy and sensitivity.
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