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UNCHARGED MORPHOLINO-BASED POLYMERS HAVING PHOSPHOROUS-CONTAINING CHIRAL INTERSUBUNIT LINKAGES
UNCHARGED MORPHOLINO-BASED POLYMERS HAVING PHOSPHOROUS-CONTAINING CHIRAL INTERSUBUNIT LINKAGES
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机译:含磷的手性基间键合的不带电荷的吗啉基聚合物
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摘要
A polymer composition is disclosed composed of morpholino subunit structures linked together by uncharged, phosphorus-containing chiral linkages, one to three atoms in length. These chiral linkages join the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.
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