MULTI-RING COMPOUNDS FOR REGULATING GUT MOTILITY, FOOD INTAKE, AND WEIGHT GAIN

摘要

Multi-ring organic compounds that regulate gut motor activity, signal satiety, and reduce food intake in an individual are described Such compounds are useful to regulate food consumption and to treat conditions of excessive weight gam and obesity. These compounds are trichothecanes or trichothecenes of Formula I: wherein x is a single or double bond and RSUB1/SUB and RSUB2/SUB are, independently, selected from the group consisting of a branched or unbranched CSUB1/SUB to CSUB6/SUB alkyl group, a branched or unbranched CSUB3/SUB to CSUB6/SUB alkenyl group, a cyclic saturated CSUB3/SUB-CSUB6/SUB ring, a monounsaturated CSUB4/SUB-CSUB6/SUB ring, an optionally substituted aryl group, and a 5 or 6-membered heteroaromatic ring