Process for the preparation of 10alpha-4'-(S-S-Dioxothothiomorpholin-1'-yl)-10-Deoxo-10-Dihydroartemisinin

摘要

Preparation of 10alpha -[4'-(S,S-dioxothiomorpholin-1'-yl)]-10-deoxo-10-dihydro-artemisinin (1a) comprises reaction of 10-halogeno-10-deoxo-10-dihydroartemisinin compound (1b) with thiomorpholindioxide compound (3) at -30[deg]C to +20[deg]C. Preparation of 10alpha -[4'-(S,S-dioxothiomorpholin-1'-yl)]-10-deoxo-10-dihydro-artemisinin (1a) comprises reaction of 10-halogeno-10-deoxo-10-dihydroartemisinin compound of formula (1b) with thiomorpholindioxide compound of formula (3) at -30[deg]C to +20[deg]C. X : halo. [Image] ACTIVITY : Antiparasitic; Antimalarial; Antibacterial. MECHANISM OF ACTION : None given.