Use of melatonin derivatives for skin depigmentation and compositions comprising the same

摘要

The use of a hydroxy-melatonin derivative of formula (I), or its salt, solvate or biological precursor, as a cutaneous depigmentation agent in cosmetic compositions is new. R1 = lower alkyl, R2 = H or lower alkyl, R3 = H or lower acyl; the OH on the indole ring is in the 4-, 6- or 7-position. Also claimed are: (i) a cosmetic method for the treatment of pigmented skin blemishes or for inhibiting tyrosinase in skin melanocytes, involving application of a cosmetic composition containing (I) to the skin; (ii) the use of (I) for the preparation of a medicament for treating pigmented blemishes; and (iii) a cosmetic or dermatological depigmenting composition comprising (I) and a carrier.