SOLID PHARMACEUTICAL COMPOSITION COMPRISING THE THIAZOLYL METHYL ESTER OF 5S-(5R*,8R*,10R*,11R*)-10-HYDROXY-2-METHYL-5-(1-METHYLETHYL)-1-2-1(1-METHYLETHYL)-4-THIAZOLYL-3,6-DIOXO-8,11-BIS(PHENYLMETHYL)-2,4,7,12-TETRAAZATRIDECAN-13-OIC ACID AND PREPARATION METHOD THEREOF

摘要

The invention relates to a solid pharmaceutical composition comprising the thiazolyl methyl ester of [5S-(5R*,8R*,10R*,11R*)]-10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-1(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-2,4,7,12-tetraazatridecan-13-oic acid and to a compound that enables gastrointestinal fluid to penetrate to penetrate said composition, which is selected from the group containing silicates and silica oxide. The invention also relates to a method of preparing said composition, comprising a mixing step in which the solvent aggregation time and speed are strictly controlled.