A VOLTAGE-GATED, PH-SENSITIVE ANION CHANNEL AND ITS NOVEL SPLICE VARIANT INVOLVED IN TASTE SENSATION

摘要

The invention provides a novel splice-variant of the C1C-4 protein, termed C1C-4A. C1C-4A is expressed in taste bud cells and is involved in sour taste perception. The invention provides C1C-4A polynucleotides and C1C-4A polypeptides, vectors, host cells and C1C-4A specific antibodies as well as designing high potency taste stimuli, determining taste preferences in animals, developing breed-specific foods, and modifying the taste of foods and medications.