TRITERPENES TYPE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITORS AND THE PREPARATION METHOD AND THE USE

摘要

The present invention relates to a class of triterpenes type PTP1B inhibitors having structures as below. Pharmacological studies indicate that this class of compounds or the physiological acceptable salts thereof have inhibitory activity against PTP1B and they can be used as insulin sensitizers and manufacture of a medicament for the treatment of disease caused by insulin resistance. The present invention relates to the preparation method of this class of compounds.