COMPUTATIONAL METHOD FOR DESIGNING ENZYMES FOR INCORPORATION OF AMINO ACID ANALOGS INTO PROTEINS

摘要

The present invention provides the analogs of a kind of method, reagent and calculating instrument design non-natural substrates to be used for enzyme, in particular for the aminoacyl tRNA synthetase (AARSs) of the analog of design unnatural amino acid, such as phenylalanine tRNA synzyme. In the analog for being incorporated into unnatural amino acid the present invention also provides method, especially those interesting functional groups enter that protein product is protein-modified or new function to generate.