ADENOVIRAL VECTORS COMPRISING A NUCLEIC ACID ENCODING A MHC CLASS I MOLECULE AND THE USE OF SUCH VECTORS IN CANCER THERAPY.

摘要

The present invention provides compositions and methods for facilitating expression of genetic material encoding an immunogenic molecule on the surface of a target cell. In particular, the present invention relates to a method for facilitating expression of genetic material encoding a major histocompatibility (MHC) protein on the surface of cancer cells in order to induce an immune response against such cells. Even more particularly, the subject invention provides viral vectors encoding MHC molecules foreign to a host for use in facilitating expression of such molecules on the surface of cancer cells in order to induce an immune response against the cells.