NOVEL 3-D POLYMER SCAFFOLD FOR TISSUE REGENERATION AND PREPARATION METHOD THEREOF

摘要

The invention relates to a novel 3-D polymer scaffold for tissue regeneration, having a porous structure which is the inverse or negative of a three-dimensional porogen or template (figure 1) resulting from the sintering of stacked meshes of nylon fibres. The invention is characterised by a regular orthogonal network (figures 2 to 5) comprising aligned and interconnected pores and cylindrical channels of uniform size and free of residual porogen, with a variable porosity of more than 75 % and a variable channel and pore diameter of the µm order of magnitude. The novel polymer scaffold is obtained by: infiltration and polymerisation of the cross-linking material in the template, elimination of the porogen by means of leaching, and drying of the resulting porous matrix. Said scaffold is chemically and mechanically stable and is particularly suitable for use in the regeneration or repair of human or animal tissues.