USE OF PKC-ACTIVATING COMPOUNDS AS CARDIOPROTECTANTS AND AS APOPTOSIS-INDUCING ANTI-TUMOR AGENTS

摘要

Compounds for the inducing apoptosis in cancer cells are described. The described compounds induce the translocation of protein kinase C-δ to the mitochondria and the phosphorylation of mitochondrial phospholipid scramblase 3. The compounds also provide cardioprotection through the translocation and activation of protein kinase C-ϵ in cardiomyocytes, thereby inhibiting apoptosis in carciomyocytes.