SOLID PHASE SYNTHESIS OF ANTITUMORAL COMPOUNDS

摘要

Lamellarins are prepared using a solid phase synthesis. In a first aspect, the process includes a step as follows: Formula (I) where R1 to R15 are as defined, and X is halogen, provided that one of R2, R3 or R4 is immobilised to a resin. In a second aspect, the process includes a step as follows: Formula (II) where R1' to R5', R11' and R13' are as defined, X1 and X2 are halogen, M is a metal function and PG is an amino protecting group, provided that one of that R2', R3' or R4' is immobilised to a resin.