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METHOD FOR IDENTIFYING AGENTS WHICH MODULATE GTPASE ACTIVITY INVOLVED IN INSULIN-STIMULATED GLUT4 TRANSLOCATION
METHOD FOR IDENTIFYING AGENTS WHICH MODULATE GTPASE ACTIVITY INVOLVED IN INSULIN-STIMULATED GLUT4 TRANSLOCATION
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机译:确定胰岛素刺激的Glu4转运涉及的调节GTP酶活性的试剂的方法
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摘要
The present invention is a method for identifying agents that modulate the GTPase activity of AS160. In the instant assay, AS160 or the GAP domain thereof is contacted with a test agent, in the presence of GTP-bound Rab (2A, 8A, 8B, 10, or 14), and the AS160 GAP domain-mediated hydrolysis of GTP to GDP is monitored.
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