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Method for identifying agents which modulate GTPase activity involved in insulin-stimulated GLUT4 translocation
Method for identifying agents which modulate GTPase activity involved in insulin-stimulated GLUT4 translocation
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机译:鉴定与胰岛素刺激的GLUT4易位有关的调节GTPase活性的物质的方法
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摘要
The present invention is a method for identifying agents that modulate the GTPase activity of AS160. In the instant assay, AS160 or the GAP domain thereof is contacted with a test agent, in the presence of GTP-bound Rab (2A, 8A, 8B, 10, or 14), and the AS160 GAP domain-mediated hydrolysis of GTP to GDP is monitored.
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