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TGF-BETA ANTAGONISTS COMBINED WITH RENIN-ANGIOTENSIN-ALDOSTERON-SYSTEM ANTAGONISTS FOR TREATING RENAL INSUFFICIENCY
TGF-BETA ANTAGONISTS COMBINED WITH RENIN-ANGIOTENSIN-ALDOSTERON-SYSTEM ANTAGONISTS FOR TREATING RENAL INSUFFICIENCY
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机译:TGF-BETA拮抗剂与肾素-血管紧张素-醛固酮系统拮抗剂联合治疗肾功能不全
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摘要
The disclosure provides methods for treating, preventing, and reducing risk of occurrence of renal insufficiency in mammals. The disclosed methods include administering to a subject susceptible to, or afflicted with, renal disorder therapeutically effective amounts of a TGF-beta antagonist and a renin-angiotensin-aldosterone system (RAAS) antagonist so as to maintain desirable levels of renal function. The populations treated by the methods of the invention include but are not limited to patients suffering or at risk for the development of renal insufficiency, such as those afflicted with type I or type II diabetes, hypertension, (auto)immune disease, systemic fibrosis, etc.
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