METHODS OF IDENTIFYING ABERRANT RNA OR RNA TARGETED FOR CLEAVAGE BY MIRNA OR SIRNA

摘要

The invention provides novel methods of identifying RNA that is targeted for cleavage by miRNA or siRNA or genes that give rise to aberrant RNA. The invention also provides the use in processes for identifying aberrant RNA or RNA targeted for cleavage by miRNA or siRNA of mutant eukaryotic cells or non-human organisms in which the gene encoding the enzyme AtXRN4 or its homologue is defective.