PRE-TRANSPLANTATION TREATMENT OF DONOR CELLS TO CONTROL GRAFT VERSUS HOST DISEASE (GVHD) IN TRANSPLANT RECIPIENTS

摘要

Described herein are donor cells which, upon transplant, have reduced or abrogated capacity to generate a GVHD response in the recipient. A method for preparing said cells is described, as well as a composition comprising thereof. Furthermore, said cells are suitable for treatment of a number of diseases, particularly hematopoietic cell deficiency disorder, congenital or acquired immune deficiency, a genetic disorder causing hemoglobinopathy, an enzyme deficiency disease, hematological malignancies, cancer, metastatic solid tumors or autoimmune diseases. Essentially, said donor cells are suitable for administration to any subject in need of cell immunotherapy or adoptive transfer immunotherapy transplant.