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METHODS AND COMPOSITIONS FOR MODULATING THE INTERACTION BETWEEN ADIPONECTIN AND ITS RECEPTOR
METHODS AND COMPOSITIONS FOR MODULATING THE INTERACTION BETWEEN ADIPONECTIN AND ITS RECEPTOR
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机译:调节脂联素与其受体相互作用的方法和组合物
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摘要
The invention is directed to methods for identifying agents that mimic or modulate the interaction between adiponectin and its receptor. In particular, the invention is directed to methods for mimicking or modulating the adiponectin-T-cadherin interaction in order to treat diseases and disorders associated with a deficiency or overabundance of adiponectin. Such diseases include, e.g., obesity, anorexia nervosa, type I and type II diabetes, coronary artery disease and atherosclerosis. The invention also provides isolated adiponectin-T-cadherin complexes and methods for identifying polypeptides that interact with adiponectin.
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