SP1 AND SP3 TARGETED CANCER THERAPIES AND THERAPEUTICS

摘要

The invention provides methods and compositions for treating a cancerous condition, using one or more inhibitory agents that target the transcription factors Sp1 or Sp3. Compositions provided include Sp1 and Sp3-targeted antisense oligonucleotides and ribozymes and recombinant viral vectors for delivery of these ribozymes to a tumor, as well as Sp1/Sp3 specific promoters for optimized negative-feedback expression of the Sp1/Sp3 ribozymes. The invention further provides a system for analyzing the effectiveness of a cancer therapy treatment on a cancer by using an animal model in which the cancerous cells and recombinant cancer therapeutics are separately marked with different fluorescent markers that allow for the detection of effectively treated cancer cells and tissue.