PROPHYLACTIC AND THERAPEUTIC AGENTS CONTAINING POINT MUTANTS OF PROAPOLIPOPROTEIN A-I FOR ANTI-ATHEROSCLEROSIS AND ANTI-HYPERLIPIDEMIA

摘要

The proapoA-I mutants of the present invention exhibit superior LDL-antioxidant activities over the wild-type proapoA-I and higher efficiencies for delivering cholesterol to hepatocytes than the previously reported apoA-I-R173C, and thus they can be effectively used for prevention and treatment of hyperlipidemia or atherosclerosis.