Prophylactic and therapeutic agents containing point mutants of proapolipoprotein A-I for anti-atherosclerosis and anti-hyperlipidemia

摘要

The present invention pro Apo and lipoprotein A-1 variant, relates to a hyperlipemia or arteriosclerosis preventive and therapeutic agents comprising the same, more specifically to Arg-His-Phe-Trp in the amino-terminal of apo-lipoprotein (apoA-I) -Gln-Gln, which pro Apo lipoprotein (proapo AI) 154 times in the apo AI include, 155 times, 156 times, 157 times or proapo containing a mutation at position 158 in the AI ​​variants of, nucleic acid encoding the mutant , it relates to a recombinant vector, hyperlipidemia or arteriosclerosis preventive and therapeutic agent containing the above transformant and a mutant transduced with the vector as an active ingredient comprising the above nucleic acid. ; Businesses Apo AI lipoprotein variants, hyperlipidemia, atherosclerosis