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INHIBITION OF TRP CHANNELS AS A TREATMENT FOR CARDIAC HYPERTROPHY AND HEART FAILURE
INHIBITION OF TRP CHANNELS AS A TREATMENT FOR CARDIAC HYPERTROPHY AND HEART FAILURE
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机译:抑制TRP通道治疗心脏肥大和心脏衰竭
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摘要
The present invention provides methods of treating and preventing cardiac hypertrophy and heart failure. MEF-2, NF-AT3, calcineurin, MCIP, and Class II HDACs have been shown to have a major role in cardiac hypertrophy and heart disease, and inhibition of many of these factors or the pathways mediated by these factors has been shown to have a beneficial, anti-hypertrophic effect. The present invention provides a link between these factors and the pathways they mediate through a family of non-voltage gated channels called TRP channels. The present invention further demonstrates that inhibitors of TRP channels can inhibit or treat heart failure and cardiac hypertrophy.
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