MUTANT STRAIN HAVING HYPERPRODUCTIVITY OF PRAVASTATIN SODIUM AND THE METHOD FOR PRODUCING PRAVASTATIN SODIUM USING THEREOF

摘要

The present invention relates to a process for the preparation of pravastatin sodium and pravastatin sodium produced by this mutant, and, more particularly, as is, Streptomyces Expo Ria tooth ( Streptomyces exfoliatus var.) mutant KBT2125 (KCCM 10570) and the culture medium while maintaining the concentration of the precursor within the pravastatin constant characterized in that the mutant strain cultured relates to a process for the production of pravastatin sodium. ; The present invention mutant Streptomyces Expo Leah tooth ( Streptomyces exfoliatus ) based on KBT2125 (KCCM 10570) is converted to the excellent ability of pravastatin sodium from pravastatin sodium productivity is much higher precursor , is also continuously added to the fermentation of pectin comb optimum concentration in the culture medium has the effect of maximizing the production of pravastatin sodium.