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SPRAY DRYING OF AN ALCOHOLIC AQUEOUS SOLUTION FOR THE MANUFACTURE OF A WATER-INSOLUBLE ACTIVE AGENT MICROPARTICLE WITH A PARTIAL OR COMPLETE AMINO ACID AND/OR PHOSPHOLIPID COAT
SPRAY DRYING OF AN ALCOHOLIC AQUEOUS SOLUTION FOR THE MANUFACTURE OF A WATER-INSOLUBLE ACTIVE AGENT MICROPARTICLE WITH A PARTIAL OR COMPLETE AMINO ACID AND/OR PHOSPHOLIPID COAT
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机译:喷雾干燥酒精水溶液,用于制备具有部分或全部氨基酸和/或磷脂涂层的水不溶性活性剂微颗粒
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摘要
A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more soluble in water than the active agent. The first and second solvents are removed from the solution to produce particles comprising the active agent and the excipient. In one version, the excipient comprises an amino acid and/or a phospholipid. A pharmaceutical formulation made by a version of the invention comprises particles comprising an active agent and an excipient which at least partially encapsulates the active agent, wherein the excipient is more soluble in water than the active agent. An alcoholic aqueous solution containing a drug, which is preferably water insoluble, an amino acid and/or a phospholipid is spray dried.
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