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SPRAY DRYING OF AN ALCOHOLIC AQUEOUS SOLUTION FOR THE MANUFACTURE OF A WATER-INSOLUBLE ACTIVE AGENT MICROPARTICLE WITH A PARTIAL OR COMPLETE AMINO ACID AND/OR PHOSPHOLIPID COAT
SPRAY DRYING OF AN ALCOHOLIC AQUEOUS SOLUTION FOR THE MANUFACTURE OF A WATER-INSOLUBLE ACTIVE AGENT MICROPARTICLE WITH A PARTIAL OR COMPLETE AMINO ACID AND/OR PHOSPHOLIPID COAT
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机译:喷雾干燥酒精水溶液,用于制备具有部分或全部氨基酸和/或磷脂涂层的水不溶性活性剂微颗粒
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摘要
A method of making a pharmaceutical formulation includes providing a solution containing a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more water soluble than the active agent. The first and second solvents are removed from the solution to produce particles containing the active agent and the excipient. In one version, the excipient comprises an amino acid and / or a phospholipid. Pharmaceutical formulations prepared by the versions of the present invention contain excipients that at least partially encapsulate the active agent and the active agent, wherein the excipient is more water soluble than the active agent. Preferably an alcoholic aqueous solution comprising a drug, amino acid and / or phospholipid which is water insoluble is spray dried.
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