Preparation method of the diacid compound which can be used for the stereoselective synthesis of 13-cis-retinoic acid and all-trans-retinoic acid

摘要

The invention of the formula (I) 13 ssiseu-retinoic Acid familiar with all of the Formula 2-trans-retinoic provides a stereoselective synthesis of the wing Acid. Using the chemistry of sulfones Julia is efficiently used for the synthesis of retinol and carotene C15 sulfone compound (compound [F]) C5 haloalkyl rigs allyl diester using (compound [G]) with di-C20 sulfonic ester (compound in combination [H]) obtained, and then treated with a base to proceed at the same time as the hydrolysis-dihydro-sulfonated (dehydrosulfonation) reaction of the ester is obtained a di-C20 Acid compound of formula (3). D. Acid compound of formula 3 is 2,6-lutidine or pyridine and optionally with the reaction of the respective three-dimensional 13-ssiseu of formula I-retinoic Acid ripening of formula 2 with all-trans-retinoic Acid is to provide a ripening ; .