A Dimer of Chimeric Recombinant Binding Domain-Functional Group Fusion formed via Disulfide-bond-bridge and A Process For Producing The Same

摘要

PURPOSE: A dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and a production process thereof are provided. The dimer has two times-improved adhesion, and excellently functions on a target. CONSTITUTION: A dimer of chimeric recombinant binding domain-functional group fusion is provided, wherein an extended amino acid sequence(Ext) which is extended from the binding domain(B) to the function group(F) fuses the binding domain(B) and the functional group(F); the extended amino acid sequence(Ext) contains cysteine without an inner chain pair and forms disulfide-bond-bridge when the cysteine is oxidized; and a flexible amino acid sequence(Flx) is contained between the last cysteine and the functional group(F), and consists of flexible amino acid sequences of GASQEND, so that it can decrease steric hindrance between the functional group when the chimeric recombinant binding domain(B)-functional group(F) fusion forms the dimer.