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Pure 3R-3´R Stereoisomer of Zeaxanthin for Treating Macular Degeneration in Humans
Pure 3R-3´R Stereoisomer of Zeaxanthin for Treating Macular Degeneration in Humans
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机译:玉米黄质的纯3R-3´R立体异构体用于治疗人的黄斑变性
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摘要
Methods and formulations are disclosed for making and purifying the 3R-3R' stereoisomer of zeaxanthin as a sole detectable isomer for use as a drug or vitamin by humans, specifically for the treatment of patients suffering from macular degeneration. Zeaxanthin preparations containing only the desired 3R-3R' stereoisomer can be produced by a strain of Flavobacterium multivorum (ATCC accession number 55238). After synthesis using microbial fermentation, the zeaxanthin can be concentrated to a level of 5 to 20 percent (by weight) using simple and inexpensive means such as solvent extraction. It can also be purified to much higher levels by other methods if desired.
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