Therapeutic potential of translocator protein ligands for age-related macular degeneration

摘要

Age-related macular degeneration:Agerelated macular degeneration(AMD)is a retinal degenerative disorder,characterized by the irreversible loss of the central vision during ageing.This chronic,progressive disease has been estimated to currently affect around 196 million people worldwide and will increase to 288 million in 2040(Wong,et al.,2014).Early AMD is defined by the presence of drusen underneath the retinal pigment epithelial(RPE)layer.Late AMD can be divided into two groups,"wet AMD"and"dry AMD",depending on the underlying clinical features.