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Method for Inhibiting Growth Factor-Induced Production of Reactive Oxygen Species from Animal Cell

机译:抑制生长因子诱导动物细胞产生活性氧的方法

摘要

The present invention relates to a method for inhibiting the generation of reactive oxygen species induced by growth factors in animal cells. Method for inhibiting the generation of reactive oxygen species induced by growth factors in the cells of the invention by introducing siRNA that can be complementarily bonded with βPix genetic or Nox1 gene into a cell, inhibiting the expression of each βPix gene or Nox1 gene It includes the step of. When using the method for inhibiting the generation of reactive oxygen species induced by growth factors in the cell of the invention, a harmful activity excessive generation of reactive oxygen species induced by treatment of the growth factors such as EGF or PDGF used in sulfa It can be suppressed, with the growth factor, as well as more secure sulfa will be widely utilized for prevention and treatment of various diseases aging study. ; ROS (reactive oxygen species), growth factors, βPix, Nox1
机译:本发明涉及在动物细胞中抑制由生长因子诱导的活性氧种类的产生的方法。通过将可以与βPix基因或Nox1基因互补结合的siRNA引入细胞中,抑制每个βPix基因或Nox1基因的表达来抑制本发明细胞中由生长因子诱导的活性氧物种的产生的方法,包括步骤。当在本发明的细胞中使用抑制由生长因子诱导的活性氧物种的产生的方法时,通过处理生长因子如磺胺中使用的EGF或PDGF而诱导的有害活性过高的活性氧物种的产生可以是抑制,具有生长因子以及更安全的磺胺将被广泛用于预防和治疗各种疾病的衰老研究。 ; ROS(活性氧),生长因子,βPix,Nox1

著录项

  • 公开/公告号KR100573880B1

    专利类型

  • 公开/公告日2006-04-26

    原文格式PDF

  • 申请/专利权人 이화여자대학교 산학협력단;

    申请/专利号KR20040030408

  • 发明设计人 배윤수;박혜선;

    申请日2004-04-30

  • 分类号A61K48;

  • 国家 KR

  • 入库时间 2022-08-21 21:23:54

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