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New enoic acid amide compounds having inhibitory activity against acyl-CoA:cholesterol acyltransferase, process of preparation thereof and composition comprising the same
New enoic acid amide compounds having inhibitory activity against acyl-CoA:cholesterol acyltransferase, process of preparation thereof and composition comprising the same
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机译:对酰基辅酶A:胆固醇酰基转移酶具有抑制活性的新烯酰胺化合物,其制备方法和包含该化合物的组合物
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摘要
The invention acyl Koei: novel enoic acid amide compound cholesterol transition having enzyme inhibitory activity, relates to their preparation and compositions containing them, wherein enoic acid amide-based compound is Mai Larsen 2 (Mylacen 2) or Mai characterized in that Larsen 3 (Mylacen 3). ; Enoic acid amide compound miter Larsen 2 or Mai Larsen 3 of the present invention are acyl-Koei: Because cholesterol transition effectively inhibit the activity of the enzyme, acyl-Koei: hyperlipidemia cholesterol transition associated with the enzyme, coronary heart disease, arteriosclerosis It can be useful in the prevention and treatment of heart and circulatory diseases such as atherosclerosis and myocardial infarction.
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