首页> 外国专利> BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLYLACTIDE-??-GLYCOLIDE POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES

BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLYLACTIDE-??-GLYCOLIDE POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES

机译:具有可逆热凝胶化特性的可生物降解的低分子量三嵌段聚丙交酯-β-乙交酯聚乙烯乙二醇共聚物

摘要

A water soluble biodegradable ABA- or BAB- type triblock polymer is disclosed that is made up of a major amount of a hydrophobic polymer made up of a poly(lactide-co-glycolide) copolymer or poly(lactide) polymer as the A-blocks and a minor amount of hydrophilic polyethylene glycol polymer B-block, having an overall weight average molecular weight of between about 2000 and 4990, and that possesses reverse thermal gelation properties. Effective concentrations of the triblock polymer and a drug may be uniformly contained in an aqueous phase to form a drug delivery composition. The release rate of the drug may be adjusted by changing various parameters such as hydrophobic/hydrophilic component content, polymer concentration, molecular weight and polydispersity of the triblock polymer. Because the triblock polymer is amphiphilic, it functions to increase the solubility and/or stability of drugs in the composition, as demonstrated by a phase diagram illustrating the gelation behaviour of aqueous solutions of a PLGA-PEG-PLGA triblock copolymer studied at different concentrations and temperatures.
机译:公开了一种水溶性的可生物降解的ABA-或BAB-型三嵌段聚合物,其由大量由聚(丙交酯-共-乙交酯)共聚物或聚(丙交酯)聚合物作为A-嵌段的疏水性聚合物组成。以及少量的亲水性聚乙二醇聚合物B-嵌段,其总重均分子量为约2000-4990,并且具有反向热胶凝性能。三嵌段聚合物和药物的有效浓度可以均匀地包含在水相中以形成药物递送组合物。可以通过改变各种参数来调节药物的释放速率,所述参数例如疏水性/亲水性成分含量,聚合物浓度,三嵌段聚合物的分子量和多分散性。因为三嵌段聚合物是两亲的,所以它的作用是增加药物在组合物中的溶解度和/或稳定性,如通过相图所说明的,该相图说明了在不同浓度下研究的PLGA-PEG-PLGA三嵌段共聚物的水溶液的胶凝行为。温度。

著录项

  • 公开/公告号KR100633939B1

    专利类型

  • 公开/公告日2006-10-16

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR20007003583

  • 申请日2000-04-03

  • 分类号C08G63/91;

  • 国家 KR

  • 入库时间 2022-08-21 21:22:49

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