PROCESS FOR THE PREPARATION OF ORTHO-SUBSTITUTED ARYLMETAL COMPOUNDS AND THEIR REACTION WITH ELECTROPHILIC REAGENTS

摘要

The present invention is alkyl in the presence of a secondary metal amide of a catalytic amount of - or by using an aryl metal compound or metal hydride to an aromatic compound characterized by deprotonation Sikkim, at least one halogen atom, a trifluoromethoxy group, a dialkylamino group, a nitrile group, an alkoxy group or dialkyl amido against group ortho by deprotonation of aromatic compounds having a hydrogen atom at the ortho position - how to make and reacting this compound with an electrophilic reagent to a substituted aryl metal compound to relate.